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Medications and Injections for Weight Loss

Medications And Injections for Weight Loss

Medications and injections for weight loss are available, particularly for individuals with obesity or overweight conditions.

Medications for Weight Loss

Prescription weight loss drugs are medications approved by the FDA to help individuals with obesity or overweight achieve and maintain a healthy weight. These medications are typically used in conjunction with a reduced-calorie diet and regular exercise. Here are some key points about prescription weight loss medications:


  • BMI Requirements: Prescription weight loss drugs are usually indicated for obese patients with a body mass index (BMI) greater than 30 kg/m² or overweight patients with a BMI greater than 27 kg/m² in the presence of other risk factors such as high blood pressure, type 2 diabetes, high cholesterol, or sleep apnea.
  • Health Risks: These medications are often used as a “second-line” treatment for individuals who have not been successful with diet and exercise and have significant health risks associated with being overweight or obese.

Types of Medications

  • GLP-1s: The newest class of drugs that treat both type 2 diabetes and obesity work with both of the main digestive hormones that tell the body to make insulin: GLP-1 and glucose-dependent insulinotropic polypeptide (GIP-1).
  • Orlistat (Xenical, Alli): Orlistat functions by approximately 30% reducing the amount of fat absorbed in the intestine. It is approved for long-term use and can help individuals lose up to 6 pounds (3 kg) or up to 6% of body weight.
  • Phentermine-Topiramate (Qsymia): This medication combination helps reduce appetite and can lead to significant weight loss.
  • Naltrexone-Bupropion (Contrave): This medication combination helps reduce appetite and can lead to significant weight loss.
  • Liraglutide (Saxenda): This medication is approved for both type 2 diabetes and obesity and can help individuals lose up to 10% of their body weight.
  • Semaglutide (Wegovy): This medication is approved for both type 2 diabetes and obesity and can help individuals lose up to 10% of their body weight.
  • Setmelanotide (IMCIVREE): This medication is limited to individuals with specific rare genetic disorders and is not suitable for general use.
  • Berberine: Berberine, a natural compound derived from various shrubs, has gained popularity as a potential weight loss aid. It has been found to have various health benefits, including weight loss, blood sugar management, and more.
  • Trulicity: Trulicity is a glucagon-like peptide-1 (GLP-1) receptor agonist medication primarily used to manage type 2 diabetes. While it is not FDA-approved for weight loss, it has been shown to help individuals lose weight, particularly when combined with diet and exercise lifestyle changes.
  • Metamucil: Metamucil can help reduce hunger and appetite, which may lead to reduced calorie intake and potentially support weight loss when combined with a balanced diet and exercise.
  • Jardiance: Jardiance can help with weight loss in people with type 2 diabetes, but it is not specifically approved for weight loss. Jardiance (empagliflozin) at the 10 mg or 25 mg dose had an average weight loss of 2.8% and 3.2% of their baseline weight, respectively, over 24 weeks.
  • Mounjaro: It help adults with obesity or weight-related health issues by influencing appetite and improving insulin regulation to aid in weight loss. Taking Mounjaro for 72 weeks lost an average of 15% of their body weight.
  • Inositol: A naturally occurring sugar-like compound, may be beneficial for weight loss, particularly for individuals with conditions like polycystic ovary syndrome (PCOS) or those who are overweight or obese.

Side Effects and Risks

  • Digestive Side Effects: Many of these medications can cause digestive side effects such as nausea, constipation, and stomach pain.
  • Serious Side Effects: Some medications can have more serious side effects, such as depression, which some people who are obese struggle with already.
  • Long-term Use: Prescription weight loss medications are typically used long-term, and individuals may need to take them indefinitely to maintain weight loss.

Availability and Insurance Coverage

  • Insurance Coverage: Many insurance plans do not cover weight loss medications, and those that do may have high copays or require a “stepped-therapy” plan, where other weight loss options are tried first.
  • Medicare Part D: Medicare Part D may cover weight loss drugs if they are prescribed to treat another health condition like diabetes.

Alternative Options

  • Clinical Trials: Clinical trials are an important part of the process by which new drugs become available. Individuals can participate in clinical trials to help doctors learn more about ways to lose weight and keep it off.
  • Herbal Remedies and Supplements: Many herbal remedies and supplements claim to help with weight loss, but these claims are often not supported by scientific evidence and can have serious side effects.

Important Notes

  • Pregnancy and Breastfeeding: Prescription weight loss medications should not be taken during pregnancy or breastfeeding.
  • Lifestyle Changes: Weight loss medications are most effective when used in conjunction with a reduced-calorie diet and regular exercise. Individuals should make lasting lifestyle changes to maintain weight loss.

Injections for Weight Loss

Injections for weight loss are a type of medication that can help individuals manage their weight. The most commonly used FDA-approved injections for weight loss are semaglutide (Wegovy) and liraglutide (Saxenda). These medications work by mimicking the effects of hormones in the body, such as incretins, which help regulate blood sugar levels and appetite.

How Do Weight Loss Injections Work?

Semaglutide (Wegovy):

  • Semaglutide is a GLP-1 receptor agonist that helps stimulate the pancreas to produce more insulin, which aids in sugar absorption and energy production.
  • It also lessens appetite, which helps people lose weight.
  • Wegovy is approved for adults with obesity (BMI ≥30) or overweight (BMI ≥27) with weight-related medical problems.

Liraglutide (Saxenda):

  • Saxenda is also a GLP-1 receptor agonist that helps regulate blood sugar levels and appetite.
  • It is approved for adults with excess weight (BMI ≥27) who have weight-related medical problems or obesity (BMI ≥30), as well as children aged 12-17 with obesity.

Common Sites for Injections

While the abdomen is the most common site for GLP-1 agonist injections, other areas such as the upper arms, outer thighs, upper buttocks, hips, and lower back can also be used.

Side Effects and Risks

  • Common side effects of GLP-1 agonists include nausea, vomiting, diarrhea, dizziness, increased heart rate, headache, stomach upset, and infection.
  • There is also a risk of thyroid cancer and medullary thyroid cancer, especially with prolonged use.

Cost and Insurance Coverage

The cost of these injections can vary depending on the insurance plan and the specific medication. As of May 2023, the prices for a typical monthly supply are:

  • Wegovy: £199-£299 per pen
  • Saxenda: £54-£249 per pen

Insurance coverage may require approval for the medication, and some drug manufacturers may offer temporary savings programs.


Weight loss injections, such as Wegovy and Saxenda, are prescription medications that can help individuals manage their weight by regulating blood sugar levels and appetite. While they have been shown to be effective, they also come with potential side effects and risks. It is essential to consult with a doctor and insurance providers to determine the best options for your specific situation.


1: Is sparkling water good for weight loss?

Yes, sparkling water can be beneficial for weight loss. Here are some key points:

  • Hydration: Sparkling water is an excellent way to stay hydrated, which is crucial for weight loss. Dehydration can lead to mixed signals between hunger and thirst, causing overeating. Drinking enough water helps to avoid this confusion.
  • Boosts Metabolism: Drinking cold sparkling water can help boost metabolism by forcing the body to heat it up, which can aid in digestion and energy conversion.
  • Weight Management: The carbonation in sparkling water takes up more space in the stomach, contributing to feelings of fullness. This can help reduce the likelihood of overeating and support weight loss.
  • Improved Digestion: Sparkling water can help soothe digestive issues like constipation, which can contribute to weight gain.
  • No Calories: Sparkling water typically has zero calories, making it a better alternative to sugary drinks like soda and juice.
  • Sustainable Hydration Habits: Drinking sparkling water can support sustainable hydration habits, which are essential for overall health and weight loss.

Overall, while sparkling water does not directly burn fat, it can support weight loss efforts by promoting hydration, boosting metabolism, and aiding digestion.

2: Is steak good for weight loss?

Yes, steak can be good for weight loss. Here are some reasons why:

  • High Protein Content: Steak is an excellent source of protein, which helps with satiety and can lead to weight loss. High-protein diets have been shown to induce weight loss by increasing satiety and reducing hunger.
  • Low Carbohydrate Content: Steak is a low-carb food, which is beneficial for weight loss. Consuming fewer carbohydrates can help reduce insulin resistance and promote weight loss.
  • Satiety: Steak is highly satiating, meaning it can help you feel full for longer. This can lead to fewer snacks and a lower overall caloric intake, which is essential for weight loss.
  • Nutrient-Dense: Steak is a nutrient-dense food, providing essential vitamins and minerals like selenium, iron, zinc, niacin, vitamin B6, and vitamin B12. These nutrients support overall health and can contribute to weight loss.
  • Muscle Development: Steak’s high protein content supports muscle development, which can enhance metabolism and lead to weight loss.
  • Healthy Cooking Methods: Cooking steak using methods like grilling, broiling, or roasting can help reduce added fats and calories, making it a healthier option for weight loss.

While steak can be part of a weight loss diet, it is essential to maintain a balanced diet and portion control to achieve optimal results.

3: Where to apply progesterone cream for weight loss?

To apply progesterone cream for weight loss, it is recommended to apply it to areas of the body where the skin is thinner and blood flow is higher. These areas include:

  • Hands
  • Face
  • Chest
  • Breasts
  • Inner arms
  • Inner thighs
  • Behind the knees

These areas allow for better absorption of the cream into the bloodstream, which can help with hormone balancing and weight loss.

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